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For example, senescent astrocytes show upregulated expression of IL-6, IL-8, IL-1, MMP3, MMP10, and TIMP2, while neuroprotective factors such as IL-10, NGF (nerve growth factor), and BDNF (brain-derived neurotrophic factor) are downregulated (Lye et al., 2019)

People With Chronic Kidney Conditions High doses of glutathione may affect kidney function, so those with pre-existing kidney concerns should be assessed prior to treatment

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GHK-Cu also influences the ubiquitin-proteasome system (UPS), upregulating dozens of genes involved in protein degradation and cellular maintenance, thereby supporting proteostasis under stress conditions (Pickart and Margolina 2018)

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