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Phase 2 combination trials reported 35-40% discontinuation rates due to GI side effects when both agents were dosed simultaneously

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f , Docking of flavan-3-on-4-ol ( 7 ) (yellow) into the active site of Pt GSTF8 and distances (in ) from the GSH (green) thiolate to C-2 and O-3 of 7 as well as distance of the C13 thiolate (purple) to GSH (green) 7

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Bromocriptine (D2-like receptor agonist) has been examined to treat some forms of epilepsy (Saie and Sills, 2005), lisuride (D2-like receptor agonist) may reduce seizures after traumatic brain injury (Zweckberger et al., 2010), and various D2-like receptor agonists have neuroprotective effects against kainic acidinduced brain damage (Micale et al., 2006)