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Asthma Asthma is a persistent inflammatory condition of the airways that is accompanied by structural alterations, such as an increase in smooth muscle and the remodeling of the airway wall [64]

While KA activates Notch signaling, activity of CyclinD1 is increased through AKT/glycogen synthase kinase-3 (GSK-3) signaling pathway, which leads to the transformation and abnormalities in G 1 -S in CCR [64]

Ethics declarations Conflicts of interest The Authors declare no conflict of interests

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These findings underscore the critical role of mitochondrial dysfunction in the pathogenesis of GWS and suggest that targeting impaired energy metabolism may offer novel therapeutic avenues

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