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This is how we break it down internally when consulting with research partners

[1] Kids and teens (4-18) Research suggests that this age group should expect to increase their vitamin B12 dosage every 3 to 4 years until age 14

In the absence of these bases, the outcome might be minimal

doi: 10.1038/s42003-022-03189-z 211 OuwendijkW

Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies

Oral versus intramuscular administration It is suggested that passive absorption of B 12 following sufficiently high oral doses (2000 mcg) can result in up to 10-12 mcg being absorbed daily7 and may allow serum B 12 concentrations to normalise