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In particular, this variant produces an altered fixation of SP1 and PC4 transcription factors in the promoter, resulting in a decreased transcription activity (Sousa et al., 2009) and rs38841 in Japanese population patients (Thanseem et al., 2010)

This discrepancy may arise in part because the majority of B12 in serum is bound to the transport protein haptocorrin which is not physiologically active and thus unavailable for B12-dependent enzymatic reactions in cells (Green et al., 2017)

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TB-500 is a synthetic peptide modeled after thymosin beta-4 and is commonly examined in animal models for its influence on cell migration, actin regulation, and muscle repair