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The prime injuries were induced centrally (i.e., spinal cord compression [76,77], stroke [38], brain trauma [78])

Some patients may require treatment 4 to 5 days per week in phase one while others may only need treatment 2 to 3 days per week

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It may potentially phosphorylate various target proteins, thus initiating downstream cellular responses

Importantly, no serious adverse events have been documented in over 100 preclinical studies (Sikiric et al., 2016)

A standard on/off cycle of 2 months on and 4 weeks off is a commonly used approach