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Each group consisted of six animals

doi: 10.2147/JMDH.S408117

The incidence of adverse reactions, including nausea, vomiting, headache, and mild gastric discomfort, was recorded and compared between the two groups during the treatment period

Antoine Salzmann, Sarah-Naomi James, Dylan M Williams, Marcus Richards, Dorina Cadar, Jonathan M Schott, William Coath, Carole H Sudre, Nishi Chaturvedi, Victoria Garfield, Investigating the Relationship Between IGF-I, IGF-II, and IGFBP-3 Concentrations and Later-Life Cognition and Brain Volume, The Journal of Clinical Endocrinology & Metabolism , Volume 106, Issue 6, June 2021, Pages 16171629

Treatment courses often extend for at least three to six months before meaningful cosmetic changes might be appreciated, and continued application may be required to maintain any gains

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