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Pleasants RA, Vaughan LM, Williams DM et al

M.GotzJ.KiernanM

By restoring the balance between A1AT and neutrophil elastase, the therapy helps in controlling the chronic inflammatory state that contributes to lung tissue damage ( In the lungs of individuals with enzyme deficiency, the overexpression of free neutrophil elastase stimulates the release of leukotriene B4 (LTB4) by interacting with surface receptors on alveolar macrophages

[DOI] [PubMed] [Google Scholar] 41.Tan J.L., Stam J., van den Berg A.P., van Rheenen P.F., Dekkers B.G., Touw D.J

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AST-treated wounds showed noticeable contraction by day 3 of treatment and complete wound closure was observed by day 9, while the wounds without AST application showed only partial epithelialization and still carried scabs