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Once positive expression is confirmed, DNA sequencing should be performed to ensure no errors were introduced during the PCR amplification or ligation

For example, the lysosomal cysteine protease cathepsin B (CTSB) promotes autophagy-dependent ferroptosis via translocation from lysosome into nucleus to cause DNA damage signals and to activate stimulator of interferon response cGAMP interactor 1 (STING1, also known as STING or TMEM173)-dependent DNA sensor pathways (39) ( Figure 2 )

Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling

Medintz, I

J.BlumbergB.CaveM.MachtingerR.MantovaniA.MendezM

Role of the dsRNA-dependent protein kinase (PKR) in the attenuation of protein loss from muscle by insulin and insulin-like growth factor-I (IGF-I) Mol Cell Biochem