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Administration of AC reduced oxidative stress shown by lower ROS and MDA levels, alongside increased SOD and catalase levels

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Figure 2: The pineal glands anatomical position within the neuroendocrine hub explains its outsized influence on circadian, immune, and hormonal systems, making Epitalons tissue-specific action particularly significant

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Conversely, specific phospholipid peroxidation products generated during ferroptosis can impair dendritic cell maturation, whereas factors such as CXCL10 and HMGB1 released by ferroptotic cancer cells promote the infiltration of immunosuppressive polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs)

The mixture encompassing a molar ratio of 10:1 has been proven to guarantee the best results in terms of bioreceptor surface coverage and kinetic parameters