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That is one reason human data still matters

Glutathione is also an efficient electron donor during the ROS detoxification process and oxidation to GSSG (Asada 1994)

C.LittlejohnP

We show that accumulated mutant-p53 protein suppresses the expression of SLC7A11 , a component of the cystine/glutamate antiporter, system x C , through binding to the master antioxidant transcription factor NRF2

Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG

The results showed that 4-day high glucose treatment significantly suppressed the gene expression of both OXTR (see Figure 1A) and OXT (see Figure 1B)