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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Among the screened compounds, the thiamidol scaffold (Figure 11) emerged as the most potent chemotherapeutic anti-hTYR inhibiting agent and demonstrated an excellent IC 50 value of 1.1 M, while in the case of mTYR enzyme, compound displayed very low inhibition activity with an IC 50 value of 108 M

Interestingly, it has even demonstrated that deglycosylation of some flavonoid glycosides by far-infrared irradiation can be improved tyrosinase inhibitory activity 243

Biomaterials 185, 2538

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