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Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53

Therefore, these epigenetic modifiers have been targeted for drug development for several years [171,172,173]

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In addition to BRCA genes, mutations in other high-penetrance genes such as TP53 (associated with Li-Fraumeni syndrome) and PTEN (linked to Cowden syndrome) have been found to be associated with familial breast cancer, as these genes are heritable, keeping women at potential risk to develop cancer during their lifetime ( PALB2, ATM , and CHEK2 (63)

Recently, scientists have shown that PIRA, an innate myeloid cell receptor, can recognize allo-MHC I molecules

Het glutathiontransportsysteem in de darm is zowel Na + - als Ca 2+ -afhankelijk
