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This preparation permits intravital imaging of the unperturbed meninges and brain parenchyma

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While the precise molecular pathways activated by neural PAR1 are yet under investigation, in the brain PAR1-activation has been shown to modulate synaptic transmission and plasticity through the enhancement of N-methyl-D-aspartate receptor (NMDAR) currents (Gingrich et al., 2007

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