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Mass spectrometrybased approachessuch as label-free quantification, TMT labeling, or targeted MRM/PRM workflowscan capture changes in phosphorylation states, transport proteins, metabolic enzymes, and signaling intermediates

The safety profile observed in these studies was equally impressive

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2024), derived from the antidepressant fluoxetine, was cytotoxic at concentrations higher than 0.5 mM and induced a significant increase in mean TI in all four liver cell models (Table 4 and Fig