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Lowering homocysteine levels by supplementing with B vitamins has been shown to reduce the rate of brain atrophy in elderly people with mild cognitive impairment.[ref] Researchers have found that high homocysteine exacerbates amyloid-beta-induced cell death in the brain.[ref] Osteoporosis: Researchers think the connection between high homocysteine and osteoporosis could be due to dysregulation of the transsulfuration pathway rather than a problem with the remethylation of homocysteine

Brain target occupancy of LY3372689, an inhibitor of the O-GlcNAcase (OGA) enzyme, following administration of single and multiple doses to healthy volunteers

Lengsfeld, S

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In addition, investigation of the mitochondrial function of 1919 PSPH amp and PSPH V116I GBM cells revealed an elevated proton leak in 1919 GBM PSPH V116I cells (Fig