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Wise, Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants, The Journal of Pediatrics, Volume 121, Issue 5, 1992, Pages 710-714, ISSN 0022-3476, Bell, D

Boudreau, S.A

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Standard injectable dosing ranges from 0.25 mg to 0.5 mg daily for most applications

Furthermore, the threshold effect is consistent with the concept that methionine synthase activity may become saturated beyond a certain B12 concentration [17], explaining the diminishing returns observed at higher levels