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A meta-analysis of eight controlled trials with a supplement time course ranging from a few weeks to five months suggests that there might be an optimal dose of vitamin C that can reduce oxidative stress without impairing training adaptations

Cellular and Tissue Stress and Their Impact on Insulin Function 3.1

doi: 10.3390/pathogens9010014, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] World Health Organization

Long-term users often describe a normalization of mental function rather than a sense of enhancement

Elevated ROS levels can trigger NLRP3 inflammasome activation, subsequent caspase-1 activation and gasdermin D (GSDMD) cleavage, ultimately inducing pyroptosis

Low vitamin C intake has been linked with increased cholesterol concentration in bile, and a study showed regular vitamin C users were 66% less likely to have gallstones than those who did not use it