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Briefly, 6- to 8-week-old mice were anesthetized with 1.5% sodium pentobarbital and positioned on a heating pad

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doi: 10.3389/fphar.2025.1662341 Received 09 July 2025 Accepted 28 August 2025 Published 25 September 2025 Volume 16 - 2025 Edited by Johnson O

Other factors including IGF1, GH itself, ghrelin and synthetic GH secretagogs (GHSs) can modulate the synthesis and/or release of GH by somatotrophs in vertebrates ( Figure 1 ) (59)

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However, since 80-90% of cases of hereditary hemochromatosis among Caucasians are associated with either C282Y homozygozity or C282Y/H63D compound heterozygozity, analysis of these HFE mutations is sufficient to establish the diagnosis in the vast majority of cases