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Interestingly, the TRE element in the human GCLC promoter appears to bind c-Jun dimers preferentially (Rahman et al., 1999)

Analytical approaches for quantification of a Nrf2 pathway activator: Overcoming bioanalytical challenges to support a toxicity study

Reduces oxidative stress Glutathione reduces oxidative stress by neutralizing free radicals and can recycle itself back into its active form, allowing for continuous protection of DNA and mitochondria

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In type II alveolar epithelial cells, TGF-1 lowered the transcriptional activity of GCLC [72]