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More interestingly, such PI-tolerance of B-ALL cells can be transmitted to sensitive cells by releasing exosomes (Ge et al., 2020)

[PubMed: 19271347] 70

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Statistical significance was tested using a two-tailed Student t test, with protection against type I errors set at 5%

A larger clinical trial randomly assigned more than 500 patients with type 2 diabetes and symptomatic peripheral neuropathy to one of the following treatments: (i) 600 mg/day of intravenous lipoic acid for three weeks followed by 1,800 mg/day of oral lipoic acid for six months, (ii) 600 mg/day of intravenous lipoic acid for three weeks followed by oral placebo for six months, or (iii) intravenous placebo for three weeks followed by oral placebo for six months (76)