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This activity of IRE1 is independent of its role in regulating the UPR and is evolutionarily conserved

doi: 10.1038/nature13981

ZhouYZhuFLiuYZhengMWangYZhangDet alBlood-brain barrierpenetrating siRNA nanomedicine for Alzheimers disease therapy

PMID: 20679526

In 2021, Jung et al., in Korea, investigated whether the oral intake of enzymatically decomposed collagen peptides (acid-processed collagen peptides [APCPs]: 1000 mg suspended in 25-mL samples administered once per day) could improve skin moisture and barrier function by assessing changes in the ceramide and natural moisturizing factor (NMF) contents in the stratum corneum (SC), comparing baseline parameters to end-of-treatment parameter values [37]