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On the other hand, an increase in oxidative stress markers, including those associated with DNA damage, was observed in exposed animals, along with the induction of NF-kB dependent pro-inflammatory mediators: TNF-, IL-1, IL-6 and COX-2

For instance, in the brain, it has been described that neurons operate in a strong physical and metabolic association with astrocytes and glial cells, and the dysregulation of this cooperation contributes to the development of brain disease ( Unlike other types, human brain organoids are usually generated only from human pluripotent stem cells (both hESCs and hiPSCs), mainly due to the low regenerative capacity of the adult human brain (Tang et al., 2022)

Sensitivity to ascorbic acid may also be determined by the expression of sodium-dependent vitamin C transporter-2 (SVCT-2), which transports ascorbic acid into cells (121)

Pernicious AnemiaPernicious anemia is a blood disorder in which the body does not make enough red blood cells due to a lack of vitamin B12 in the blood

10.1016/j.jdermsci.2020.03.001 180

Microsomal GSTs are membrane-associated proteins in eicosanoid and glutathione metabolism (6,7)