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Tyrosine Y123 is a key residue required for PD-L1 dimerization and for PD-1/PD-L1 binding (70, 72)

This highly conserved process is involved in the clearance of long-lived proteins and damaged organelles

The Cl, a thin sheet of grey matter subcortical structure comprised of neurons in the forebrain, is thought to have extensive connectivity with the cerebral cortex and may serve as a limbic-sensory-motor interface 58

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