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The clinical manifestations of HH include to various degrees, hepatomegaly, cirrhosis, hepatocellular carcinoma, diabetes mellitus, hypogonadotrophic hypogonadism, impotence, hypothyroidism, restrictive cardiomyopathy, arrhythmias, heart failure, destructive arthropathy and hyperpigmentation

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In contrast, ShHTL1 and ShHTL3 showed no hydrolytic activity toward rac -GR24, while ShHTL1 had weak 5DS hydrolytic activity, which was so weak that 5DS-dependent germination was not observed in transgenic lines 29

In the kidneys of diabetic mice and patients, the expression of mitotic arrest deficiency 2B (MAD2B) is upregulated