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Emerging roles of sirtuins in alleviating alcoholic liver disease: a comprehensive review

doi: 10.1002/iub.1223 43

This may be further pronounced in patients with diabetes with compromised gastrointestinal function due to autonomic neuropathy

Research has discovered that the accumulation of -2HG caused by IDH1 mutations can inhibit the amino transferases branched-chain aminotransferase 1 and branched-chain aminotransferase 2, reducing glutamate levels and increasing the synthesis of glutathione, thereby affecting tumor cell survival [149]
