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Currently, different groups are developing methods to overcome these issues based on the incorporation of vascular endothelial growth factor (VEGF) and WNT7b or co-culture methods with mesodermal progenitors generating a vascular networks (Shi et al., 2020

[DOI] [PubMed] [Google Scholar] 87.Dick DM, Smith G, Olausson P, Mitchell SH, Leeman RF, OMalley SS, Sher K

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Multiple preclinical and early clinical studies associated this species with improved insulin sensitivity, reduced adiposity, lower systemic inflammation, and enhanced gut barrier function in obesity, type 2 diabetes, and related cardiometabolic disorders (532)

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