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Firstline agents generally include serotoninnorepinephrine reuptake inhibitors (SNRIs) like duloxetine and gabapentinoids such as pregabalin, both supported by robust clinical evidence demonstrating efficacy in reducing pain intensity

The main features of the included studies are shown in Table 1

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Real-World Evidence & Preclinical Mechanism Matrix That distinction matters because the majority of long-term responders in the dataset did not describe simple short-term pain suppression

Your prescriber will determine whether your primary treatment goal is glycemic control, weight loss, or both, and adjust accordingly

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