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analyzed the intervention effects of Dioscorea extract on aging rats with chronic atrophic gastritis based on the Shh pathway and found that Dioscorea extract regulated the secretion of gastric juice, gastric acid, and pepsin, while inhibiting the progression of the disease (Li et al., 2017)

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Additionally, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) facilitated AML development and LSCs self-renewal through regulating the expression of key targets in the glutamine metabolic pathway [23]

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