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Oxidant stress induces gamma-glutamylcysteine synthetase and glutathione synthesis in human bronchial epithelial NCI-H292 cells

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Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1beta/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model

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[DOI] [PubMed] [Google Scholar] 39.Chalmers J.D., Polverino E., Crichton M.L., Ringshausen F.C., De Soyza A., Vendrell M., et al

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At therapeutic doses, vitamin C acts as: A powerful immune modulator that enhances white blood cell function, increases antibody production, and activates natural killer cells that target viruses and infected cells

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Under low-oxygen conditions, NR is capable of reducing nitrite to nitric oxide (NO), and NR-derived NO appears to be among the major sources of NO in plants with impact on plant development, protection against reactive oxygen species, phytoalexin accumulation, and pathogen resistance (Rockel et al., 2002)

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ROS has long been recognized as a harmful substance, and its excessive accumulation will cause the release of inflammatory factors, enhance the adhesion of inflammatory factors to endothelial cells, and promote apoptosis and even cause cell death (Forrester et al., 2018)

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