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Pyruvate in reticulocytes is ultimately destined for transport into mitochondria as master fuel for the tricarboxylic acid (TCA) cycle carbon flux

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Once translocated to the nucleus, NF-B activates RelA (p65) via phosphorylation, promoting the transcription of key components of the NLRP3 inflammasome, including NLRP3, ASC, and caspase-1

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hCG, dopaminergic dysfunction, and psychiatric disorders The dopaminergic system, which regulates mood, reward, and motor control, is highly sensitive to hormonal fluctuations, including those induced by hCG [100]

This somehow mirrors the challenges of Psychiatry as a field in categorizing debilitating disorders (with overlapping symptoms and varied underlying mechanisms) as opposed to normal behavior