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Molecules , 25(3), 609.

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Both doses administered in PD patients were followed by more than 50 % inhibition of LRRK2 and Rab10 phosphorylation in blood, and reduced bis (monoacylglycerol) phosphate in urine, which served as biomarkers of pharmacodynamic measures, and the lower dose was better tolerated

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In cysteine-depleted cancer cells, the TCA cycle activated by KG induces cellular lipid ROS levels, thereby promoting cell death [71] [Figure 1E]