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The IP 3 stimulates release of intracellular Ca 2+ stores and DAG activates PKC

for example, the TLR4/NF-B/IL-1 signaling pathway is activated in chronic SZ patients (197), and clozapine reduces the expression of pro-inflammatory genes such as IL-1 and IL-6 by inhibiting the TLR4/NF-B pathway (198)

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Native peptide drugs, however, are generally ineffective when given orally due to low oral bioavailability, which is as a result of the physical and biochemical barriers of the gastrointestinal tract (GIT), often forcing the use of invasive parental delivery methods that lead to low patient compliance [3,4]

ChaY-HGoldingJFKeshavarzBFurmanJKimJ-SLopez-EscamezJAet al

Unlike them, it does so in a targeted way without the extras that are ultimately unwanted in many research contexts