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ClinicalTrials.gov no completed 5-Amino-1MQ human efficacy trial (evidence-gap note)

It can improve mood, lessen weakness and fatigue, and reduce tingling sensations

There is one open-label intravenous safety pilot in two healthy adults, who received single doses of 10 mg and 20 mg with no comparator, no blinding, and short-term observation limited to vital signs, self reported symptoms and labs across two days [4]

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12-Week Study: Efficacy and Safety Overview A 12-week, Phase 3, randomized, double-blind, double-dummy study evaluated the efficacy, safety, and tolerability of continuous 24-hour subcutaneous infusion of PRODUODOPA versus oral immediate-release (IR) levodopa/carbidopa (LD/CD) in patients with advanced Parkinsons disease (PD) and severe motor fluctuations

Syncope was reported in 0.8% and 0.2% of patients, respectively