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BPC-157, a gastric pentadecapeptide derived from proteolytic enzyme preparations, and TB-500, a synthetic analogue of thymosin beta-4, represent emerging agents with broad biological activity relevant to tissue repair and cytoprotection

A CIC target binding octamer sequence occurs in the promoter regions of the folate transport genes FR, PCFT, and RFC1, and dihydrofolate reductase, and binding was confirmed by chromatin immunoprecipitation assays

Ascorbate may also influence plant epigenetic processes (Ramakrishnan et al

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[DOI] [PubMed] [Google Scholar] 34.Chapple IL

doi: 10.1038/s41531-024-00771-6