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Picrotoxin acts as a competitive antagonist of GABAARs, acting on synapses as a non-competitive channel blocker for GABAARs chloride channels, specifically the GABA-activated chloride ionophore [229]

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While the exact cause isnt fully understood, Peyronies is commonly associated with: Repetitive micro-trauma or injury Genetic predisposition Connective tissue disorders Inflammation and abnormal wound healing Early intervention can help prevent progression and improve long-term outcomes

Some of these differences could be attributed to medications that are typically only used in one sex or resulted in sexspecific adverse events (eg prostate cancer)
