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For example, the NMDAR antagonist phencyclidine (PCP) can induce hyperlocomotion and PPI deficits (Shirai et al., 2012

But at this stage, hydroquinone cream remains the gold standard for treating melasma

Clinically, plasma malondialdehyde (MDA)a byproduct of lipid peroxidationserving as a biomarker of oxidative stress severity, with elevated levels correlating with accelerated lung function decline in COPD patients

While both RMORs [15] and Arr-3 KOs [59] show enhanced morphine conditioned place preference (CPP), RMOR mice, unlike WT, do not transition to compulsive drug seeking in self-administration paradigms or show reinstatement to drug seeking after extinction [15], demonstrating that reward is a flawed indicator of abuse potential

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