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Succination is a non-enzymatic, irreversible protein modification mediated by fumaric acid (an intermediate product of Krebs cycle in mitochondria) (Kerins et al., 2018)

[DOI] [PubMed] [Google Scholar] 152.Rocha A., Bolin A.P., Cardoso C.A., Otton R

Graphical abstract Access this article Similar content being viewed by others Change history 09 November 2025 The original online version of this article was revised due to incorrect email address of the author M

J Pharm Sci 2019;108:24909

Wu HM1, Tzeng NS, Qian L, Wei SJ, Hu X, Chen SH, Rawls SM, Flood P, Hong JS, Lu RB (2009) Novel neuroprotective mechanisms of memantine: Increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation

The novel synergistically acting GLP-1 RA + amylin RA formulation, CagriSema, shows promising results in both glucose control and chronic weight management