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NNMTi is an enzyme overexpressed during skeletal muscle aging and is associated with the repair of damage to the NAD+ pathway, dysregulation of sirtuin1 activity, and increased senescence of muscle stem cells

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Blood pressure and aortic stiffness decreased notably

Despite this, we still have no direct evidence that lowering Lp(a) levels reduces cardiovascular risk: the Lp(a) hypothesis is yet to be proven