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Marked elevation in plasma trimethylamine-N-oxide (TMAO) in patients with mitochondrial disorders treated with oral l-carnitine

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Increased fission caused by the upregulation of proteins Fis1 and Drp1 normally promotes mitophagy [309]

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Additionally, L-carnitine produces TMAO at the fastest rate, while betaine generates TMAO more slowly (71)

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