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McIntosh, orcid.org/0000-0001-9331-8648

Keith Lafferty MD, Fort Myers on October 10, 2025

Formulation alternatives may provide relief: Different tablet formulations with alternative inactive ingredients may be better tolerated Liquid preparations can be easier to tolerate and allow flexible dosing Intramuscular injections completely avoid the gastrointestinal tract and are particularly useful for those with absorption issues (such as pernicious anaemia or malabsorption) or persistent oral intolerance Review inactive ingredients: Examine the supplement label for potential irritants or allergens

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DOI: 10.3390/biomedicines11092515 Note: All cited research relates to pre-clinical in-vitro, ex-vivo, and animal model studies

Acknowledgements: We thank vaccinologist Geert vanden Bossche for sharing his immunological perspectives