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Pre-treatment of human primary chondrocytes with alogliptin for 24 h (25 and 50 M) prevented the degradation of type II collagen and aggrecan dose-dependently
26 The compound has been available in clinical practice for several decades to treat various medical conditions, including bronchitis, acute respiratory distress syndrome, paracetamol intoxication, chemotherapy-related toxicity, doxorubicin cardiotoxicity, heavy metal intoxication, ischemia-reperfusion cardiac injury, human immunodeficiency virus infection or acquired immunodeficiency syndrome, and neuropsychiatric disorders
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Current research continues developing stable, long-acting VIP agonists that could make this peptide practical for clinical use in allergic conditions
November 25, 2015
Didymin suppresses microglia pyroptosis and neuroinflammation through the Asc/Caspase-1/GSDMD pathway following experimental intracerebral hemorrhage
