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Mice with hepatocellular carcinoma and treated with XL413 (100 mg/kg) in combination with AZD8055 (20 mg/kg) exhibited significantly greater tumor mass reduction and increased lifespan compared to mice treated with monotherapy using either of these drugs [136]

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The consequence of competitive or irreversible inhibition of GR is a decrease of reduced glutathione levels

[DOI] [PubMed] [Google Scholar] 25.Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, Wink DA, Fukuto JM, Jackson AA, van Goor H, Olson KR, Feelisch M