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The prenylated C terminus of activated Rac1 restricts the orientation of the protein at the membrane and may promote higher affinity binding to the PLC PH domain

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See cited studies for primary sources

Essentially, it is a burn [2] and a variant of actinic keratosis which occurs on the lip

He played Jean-Michel in the revival of "La Cage Aux Folles" in 2004 and returned to Broadway in 2009 as Claude Hooper Bukowski in the Public Theaters revival of Hair