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FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models

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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Silva RA, Huang R, Morris J, et al

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To test this, we used transgenic animals expressing the transcriptional rab-11.2 p::YFP reporter, which serves as an effective fluorescent diagnostic of NHR-49 activation, though seemingly not a direct transcriptional target 23,42

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In subsequent steps, lanosterol is converted to cholesterol by a series of demethylations, desaturations, isomerizations and reductions in nineteen separate reactions

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The study, extended to two weeks, confirmed that the combination of intermittent unloading and AX determined an improvement in both soleus muscle atrophy and capillary density, compared to animals treated with continuous unloading [17]

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