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To improve the pharmacological properties and enable tumor-selectivity, the phenylazopyridine ligand was terminally functionalized with a hydroxy group that could be used for further chemical modifications

In addition to directly affecting the function of tumour cells themselves, inhibitors of the Wnt signalling pathway also promote the activation and infiltration of immune cells in the tumour microenvironment and assist in improving the tumour-killing effect

Bovine erythrocyte SOD1 (S5395, Sigma), human liver ferritin (F6754, Sigma) and rabbit liver MT2 (Sigma) standards were also run for comparison against tissue samples

T.GiovannoniG.ProctorG

Beeh KM, Beier J, Haas IC, Kornmann O, Micke P, Buhl R

These derivatives also show favourable drug properties and overcome colistin resistance, both in vitro and in vivo