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In a rat model of temporomandibular joint (TMJ) osteoarthritis, the nanospheres prevented structural damage to the condylar cartilage and subchondral bone, slowed the deterioration and ageing of the cartilage matrix [204]
In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]

Knief, C
10.3748/wjg.v23.i12.2106 126 VanuytselT.TackJ.FarreR
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Jahantigh HR, Rezanavaz Gheshlagh S, Mafakher L, Ahmadi N, Shahbazi B, Ahmadi K
