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Crystallographic evidence shows that homodimer subunits are related by a two-fold symmetry axis (Figure 3A&B) [73]

Elsevier Saunders, Philadelphia Maenhaut C, Christophe D, Gilbert Vassart MD (2015) Ontogeny, anatomy, metabolism and physiology of the thyroid

Lancet 351 : 13931396 Heron-Milhavet L, LeRoith D (2002) Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage

In addition, the tumor suppressor p53, which is a key regulator of apoptosis, has an essential role in apoptosis

Kagan et al., 2017)