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[7] Scopolamine is primarily metabolized by the CYP3A4 enzyme, and grapefruit juice decreases metabolism of scopolamine, consequently increasing plasma concentration
Genetic disorders like G6PD deficiency, which can make high-dose Vitamin C problematic

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Moreover, there were no differences in TOS, TAS, and OSI values between the groups of patients suffering from migraine with and without aura [33]