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In contrast, our study confirmed decreased glutathione levels and increased ROS levels through BSO treatment or GCLC silencing, and revealed that while the depletion of glutathione did not compromise lymphoma cell survival in 2D culture, it sharply diminished viability in 3D gels

Induction of DNA damage, up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes in DLA bearing mice following MMAE treatment provide an insight into apoptosis based anticancer activities of M

doi: 10.1016/j.exer.2017.02.010 61

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It contains a small -sheet, consisting of three -strands flanked by large unstructured regions and stabilized by three intramolecular disulfide-bonds as known with other -defensins